Balance within the Neurexin Trans-Synaptic Connexus Stabilizes Behavioral Control
نویسندگان
چکیده
منابع مشابه
Balance within the Neurexin Trans-Synaptic Connexus Stabilizes Behavioral Control
Autism spectrum disorder (ASD) is characterized by a broad spectrum of behavioral deficits of unknown etiology. ASD associated mutations implicate numerous neurological pathways including a common association with the neurexin trans-synaptic connexus (NTSC) which regulates neuronal cell-adhesion, neuronal circuitry, and neurotransmission. Comparable DNA lesions affecting the NTSC, however, asso...
متن کاملAlternative Splicing Controls Selective Trans-Synaptic Interactions of the Neuroligin-Neurexin Complex
Formation of synapses requires specific cellular interactions that organize pre- and postsynaptic compartments. The neuroligin-neurexin complex mediates heterophilic adhesion and can trigger assembly of glutamatergic and GABAergic synapses in cultured hippocampal neurons. Both neuroligins and neurexins are encoded by multiple genes. Alternative splicing generates large numbers of isoforms, whic...
متن کاملTrans-Synaptic Interaction of GluRδ2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum
Elucidation of molecular mechanisms that regulate synapse formation is required for the understanding of neural wiring, higher brain functions, and mental disorders. Despite the wealth of in vitro information, fundamental questions about how glutamatergic synapses are formed in the mammalian brain remain unanswered. Glutamate receptor (GluR) delta2 is essential for cerebellar synapse formation ...
متن کاملRETRACTED: Imaging Activity-Dependent Regulation of Neurexin-Neuroligin Interactions Using trans-Synaptic Enzymatic Biotinylation
The functions of trans-synaptic adhesion molecules, such as neurexin and neuroligin, have been difficult to study due to the lack of methods to directly detect their binding in living neurons. Here, we use biotin labeling of intercellular contacts (BLINC), a method for imaging protein interactions based on interaction-dependent biotinylation of a peptide by E. coli biotin ligase, to visualize n...
متن کاملRetraction Notice to: Imaging Activity-Dependent Regulation of Neurexin-Neuroligin Interactions Using trans-Synaptic Enzymatic Biotinylation
(Cell 143, 456–469; October 7, 2010) This paper introduced a new methodology, BLINC, for detecting the trans-synaptic binding of neurexin and neuroligin proteins, and applied BLINC to study the interaction dynamics of these proteins in neurons. Since this publication, my laboratory has found that BLINC cannot be reproduced in neurons using the constructs and protocols described in this paper. A...
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ژورنال
عنوان ژورنال: Frontiers in Human Neuroscience
سال: 2014
ISSN: 1662-5161
DOI: 10.3389/fnhum.2014.00052